The Placebo Effect, A new study with new results Options

Edit: Found the actual text, not just the Daily Express article:

The less technical Daily Express article:

The “placebo effect”, taking a pill with no medicinal properties, has traditionally been associated with the power of positive thinking.
Sick people often get better on the basis of this deception – with research showing the effect can be so beneficial that some doctors secretly hand out placebos to try and improve patients’ health.

But scientists believe just the “medicinal ritual” of taking a pill can help you feel better. Researchers at Harvard split 80 people with Irritable Bowel Syndrome into two groups - with one given no treatment. The other was handed sugar pills and told there was no reason they should get better. Nearly twice as many placebo patients reported effective relief in symptoms compared to the other group.
As well as 59 per cent of the placebo group improving compared to 35 per cent of the others, patients taking the dummy pills had improvement rates equivalent to patients on the most powerful IBS medications.


Read more: http://www.express.co.uk/posts/view/218980...-#ixzz19DHpuooF

Placebos without Deception:

Background
Placebo treatment can significantly influence subjective symptoms. However, it is widely believed that response to placebo requires concealment or deception. We tested whether open-label placebo (non-deceptive and non-concealed administration) is superior to a no-treatment control with matched patient-provider interactions in the treatment of irritable bowel syndrome (IBS).

Methods
Two-group, randomized, controlled three week trial (August 2009-April 2010) conducted at a single academic center, involving 80 primarily female (70%) patients, mean age 47±18 with IBS diagnosed by Rome III criteria and with a score ≥150 on the IBS Symptom Severity Scale (IBS-SSS). Patients were randomized to either open-label placebo pills presented as “placebo pills made of an inert substance, like sugar pills, that have been shown in clinical studies to produce significant improvement in IBS symptoms through mind-body self-healing processes” or no-treatment controls with the same quality of interaction with providers. The primary outcome was IBS Global Improvement Scale (IBS-GIS). Secondary measures were IBS Symptom Severity Scale (IBS-SSS), IBS Adequate Relief (IBS-AR) and IBS Quality of Life (IBS-QoL).

Findings
Open-label placebo produced significantly higher mean (±SD) global improvement scores (IBS-GIS) at both 11-day midpoint (5.2±1.0 vs. 4.0±1.1, p<.001) and at 21-day endpoint (5.0±1.5 vs. 3.9±1.3, p = .002). Significant results were also observed at both time points for reduced symptom severity (IBS-SSS, p = .008 and p = .03) and adequate relief (IBS-AR, p = .02 and p = .03); and a trend favoring open-label placebo was observed for quality of life (IBS-QoL) at the 21-day endpoint (p = .08).

Conclusion
Placebos administered without deception may be an effective treatment for IBS. Further research is warranted in IBS, and perhaps other conditions, to elucidate whether physicians can benefit patients using placebos consistent with informed consent.

Plos One trial

This post has been edited by ComaOfLoss: Dec 26 2010, 04:43 AM

Yeah, I think that is the point. (IMG:style_emoticons/default/smile.gif) I'm not sure if the way they phrased it really did matter or not; they did specifically note it was an inert placebo. I was just thinking that all the other stuff ("clinical studies... significant improvement... mind-body self-healing...") might be responsible for the patients believing they'd get better anyway.